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Subtle Deregulation of the Wnt‐Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells

The importance of the Wnt‐signaling pathway on the regulation and maintenance of the intestinal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt‐signaling pathway. Given the importance of this signa...

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Vydáno v:Stem Cells
Hlavní autoři: Young, Madeleine A., Daly, Carl S., Taylor, Elaine, James, Rhiannon, Clarke, Alan Richard, Reed, Karen Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765519/
https://ncbi.nlm.nih.gov/pubmed/29027285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2712
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