Subtle Deregulation of the Wnt‐Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells

The importance of the Wnt‐signaling pathway on the regulation and maintenance of the intestinal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt‐signaling pathway. Given the importance of this signa...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Young, Madeleine A., Daly, Carl S., Taylor, Elaine, James, Rhiannon, Clarke, Alan Richard, Reed, Karen Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Tissue‐Specific Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765519/
https://ncbi.nlm.nih.gov/pubmed/29027285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2712
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