Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease

Hyaluronan (HA), a major component of the extracellular matrix, is secreted by airway structural cells. Airway fibroblasts in allergic asthma secrete elevated levels of HA in association with increased HA synthase 2 (HAS2) expression. Thus, we hypothesized that HA accumulation in the airway wall may...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Walker, Julia K. L., Theriot, Barbara S., Ghio, Michael, Trempus, Carol S., Wong, Jordan E., McQuade, Victoria L., Liang, Jiurong, Jiang, Dianhua, Noble, Paul W., Garantziotis, Stavros, Kraft, Monica, Ingram, Jennifer L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765419/
https://ncbi.nlm.nih.gov/pubmed/28787175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0095OC
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