Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease

Hyaluronan (HA), a major component of the extracellular matrix, is secreted by airway structural cells. Airway fibroblasts in allergic asthma secrete elevated levels of HA in association with increased HA synthase 2 (HAS2) expression. Thus, we hypothesized that HA accumulation in the airway wall may...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Walker, Julia K. L., Theriot, Barbara S., Ghio, Michael, Trempus, Carol S., Wong, Jordan E., McQuade, Victoria L., Liang, Jiurong, Jiang, Dianhua, Noble, Paul W., Garantziotis, Stavros, Kraft, Monica, Ingram, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765419/
https://ncbi.nlm.nih.gov/pubmed/28787175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0095OC
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