Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles

CZE is a well‐established technique for charge heterogeneity testing of biopharmaceuticals. It is based on the differences between the ratios of net charge and hydrodynamic radius. In an extensive intercompany study, it was recently shown that CZE is very robust and can be easily implemented in labs...

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Detalhes bibliográficos
Publicado no:Electrophoresis
Main Authors: Moritz, Bernd, Locatelli, Valentina, Niess, Michele, Bathke, Andrea, Kiessig, Steffen, Entler, Barbara, Finkler, Christof, Wegele, Harald, Stracke, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Part III. Methodologies and Applications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765393/
https://ncbi.nlm.nih.gov/pubmed/28887890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.201700145
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