Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study

The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is developing and validating a mechanistic‐based assessment of the proarrhythmic risk of drugs. CiPA proposes to assess a drug's effect on multiple ion channels and integrate the effects in a computer model of the human cardiomyoc...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Mason, Jay, Sager, Philip, Patel, Vikram, Matta, Murali K., Li, Zhihua, Liu, Jiang, Garnett, Christine, Stockbridge, Norman, Zineh, Issam, Strauss, David G.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
State of the Art
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765372/
https://ncbi.nlm.nih.gov/pubmed/28986934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.896
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