Standard-dose osimertinib for refractory leptomeningeal metastases in T790M-positive EGFR-mutant non-small cell lung cancer

BACKGROUND: Osimertinib demonstrated promising efficacy for refractory leptomeningeal metastases (LM) in preclinical data and a clinical study at 160 mg, but there is limited data for the standard 80 mg dose. METHODS: T790M-positive patients with suspected LM after classical epidermal growth factor...

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Publicado en:Br J Cancer
Autores principales: Nanjo, Shigeki, Hata, Akito, Okuda, Chiyuki, Kaji, Reiko, Okada, Hideaki, Tamura, Daisuke, Irie, Kei, Okada, Hiroshi, Fukushima, Shoji, Katakami, Nobuyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2018
Materias:
Clinical Study
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765232/
https://ncbi.nlm.nih.gov/pubmed/29190637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.394
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