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Molecular determinants of Ca(2+) sensitivity at the intersubunit interface of the BK channel gating ring
The large-conductance calcium-activated K(+) (BK) channel contains two intracellular tandem Ca(2+)-sensing RCK domains (RCK1 and RCK2), which tetramerize into a Ca(2+) gating ring that regulates channel opening by conformational expansion in response to Ca(2+) binding. Interestingly, the gating ring...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5765161/ https://ncbi.nlm.nih.gov/pubmed/29323236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19029-8 |
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