Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not been reported. Herein, metformin induced pAMPK activation and pS6 suppression in metformin-sensitive (HT29) cells, but not in metformin-...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kim, Jae Hyun, Lee, Kyoung Jin, Seo, Yoojeong, Kwon, Ji-Hee, Yoon, Jae Pil, Kang, Jo Yeon, Lee, Hyun Jung, Park, Soo Jung, Hong, Sung Pil, Cheon, Jae Hee, Kim, Won Ho, Il Kim, Tae
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765079/
https://ncbi.nlm.nih.gov/pubmed/29323154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18762-4
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