Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not been reported. Herein, metformin induced pAMPK activation and pS6 suppression in metformin-sensitive (HT29) cells, but not in metformin-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kim, Jae Hyun, Lee, Kyoung Jin, Seo, Yoojeong, Kwon, Ji-Hee, Yoon, Jae Pil, Kang, Jo Yeon, Lee, Hyun Jung, Park, Soo Jung, Hong, Sung Pil, Cheon, Jae Hee, Kim, Won Ho, Il Kim, Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765079/
https://ncbi.nlm.nih.gov/pubmed/29323154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18762-4
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