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Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not been reported. Herein, metformin induced pAMPK activation and pS6 suppression in metformin-sensitive (HT29) cells, but not in metformin-...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Kim, Jae Hyun, Lee, Kyoung Jin, Seo, Yoojeong, Kwon, Ji-Hee, Yoon, Jae Pil, Kang, Jo Yeon, Lee, Hyun Jung, Park, Soo Jung, Hong, Sung Pil, Cheon, Jae Hee, Kim, Won Ho, Il Kim, Tae
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765079/
https://ncbi.nlm.nih.gov/pubmed/29323154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18762-4
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