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Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression

While human Tregs hold immense promise for immunotherapy, their biologic variability poses challenges for clinical use. Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tregs. Unlike highly suppressive but plastic memory...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Donnelly, Conor, Dykstra, Brad, Mondal, Nandini, Huang, Junning, Kaskow, Belinda J., Griffin, Russell, Sackstein, Robert, Baecher-Allan, Clare
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765004/
https://ncbi.nlm.nih.gov/pubmed/29323143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17981-z
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