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Lifting up the HAT: synthetic lethal screening reveals a novel vulnerability at the CBP-p300 axis
Cancer genotype-specific synthetic lethal vulnerabilities represent promising therapeutic targets. In this issue of Cancer Discovery, Ogiwara and colleagues uncover a synthetic lethal relationship between two histone acetyl transferase (HAT) paralogs, CBP and p300, highlighting that cancer cells def...
Shranjeno v:
| izdano v: | Cancer Discov |
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| Glavni avtor: | |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5764754/ https://ncbi.nlm.nih.gov/pubmed/27045018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0163 |
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