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Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side effects on cell viability. Using this approach, w...

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書目詳細資料
發表在:Aging (Albany NY)
Main Authors: Ozsvari, Bela, Bonuccelli, Gloria, Sanchez-Alvarez, Rosa, Foster, Richard, Sotgia, Federica, Lisanti, Michael P.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764395/
https://ncbi.nlm.nih.gov/pubmed/29253841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101351
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