Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side effects on cell viability. Using this approach, w...

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Detaylı Bibliyografya
Yayımlandı:Aging (Albany NY)
Asıl Yazarlar: Ozsvari, Bela, Bonuccelli, Gloria, Sanchez-Alvarez, Rosa, Foster, Richard, Sotgia, Federica, Lisanti, Michael P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764395/
https://ncbi.nlm.nih.gov/pubmed/29253841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101351
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