טוען...
An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53
R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain....
שמור ב:
| הוצא לאור ב: | EXCLI J |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Leibniz Research Centre for Working Environment and Human Factors
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5763090/ https://ncbi.nlm.nih.gov/pubmed/29333130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2017-299 |
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