Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

Exposure to replication-competent lentivirus (RCL) is a theoretical safety concern for individuals treated with lentiviral gene therapy. For certain ex vivo gene therapy applications, including cancer immunotherapy trials, RCL detection assays are used to screen the vector product as well as the vec...

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Foilsithe in:Mol Ther
Main Authors: Cornetta, Kenneth, Duffy, Lisa, Turtle, Cameron J., Jensen, Michael, Forman, Stephen, Binder-Scholl, Gwendolyn, Fry, Terry, Chew, Anne, Maloney, David G., June, Carl H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Gene & Cell Therapy 2018
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762981/
https://ncbi.nlm.nih.gov/pubmed/28970045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.09.008
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