Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot

The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells. This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non-coding RNA (lncRNA) gene Sox2ot. Here we show tha...

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Udgivet i:Sci Rep
Main Authors: Messemaker, Tobias C., van Leeuwen, Selina M., van den Berg, Patrick R., ‘t Jong, Anke E. J., Palstra, Robert-Jan, Hoeben, Rob C., Semrau, Stefan, Mikkers, Harald M. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762901/
https://ncbi.nlm.nih.gov/pubmed/29321583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18649-4
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