Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge

Pneumococcal flavin reductase (FlaR) is known to be cell-wall associated and possess age dependent antigenicity in children. This study aimed at characterizing FlaR and elucidating its involvement in pneumococcal physiology and virulence. Bioinformatic analysis of FlaR sequence identified three-cons...

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Publicat a:Sci Rep
Autors principals: Morozov, Giora I., Porat, Nurith, Kushnir, Tatyana, Najmuldeen, Hastyar, Adawi, Asad, Chalifa-Caspi, Vered, Benisty, Rachel, Ohayon, Ariel, Liron, Ofir, Azriel, Shalhevet, Malka, Itai, Dotan, Shahar, Portnoi, Maxim, Piotrowski, Andrew A., Kafka, Daniel, Hajaj, Barak, Fishilevich, Tali, Shagan, Marilou, Tal, Michael, Ellis, Ron, Morrison, Donald A., Mitchell, Andrea M., Mitchell, Timothy J., Dagan, Ron, Yesilkaya, Hasan, Nebenzahl, Yaffa Mizrachi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762878/
https://ncbi.nlm.nih.gov/pubmed/29321514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18645-8
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