Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge

Pneumococcal flavin reductase (FlaR) is known to be cell-wall associated and possess age dependent antigenicity in children. This study aimed at characterizing FlaR and elucidating its involvement in pneumococcal physiology and virulence. Bioinformatic analysis of FlaR sequence identified three-cons...

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Publicado no:Sci Rep
Main Authors: Morozov, Giora I., Porat, Nurith, Kushnir, Tatyana, Najmuldeen, Hastyar, Adawi, Asad, Chalifa-Caspi, Vered, Benisty, Rachel, Ohayon, Ariel, Liron, Ofir, Azriel, Shalhevet, Malka, Itai, Dotan, Shahar, Portnoi, Maxim, Piotrowski, Andrew A., Kafka, Daniel, Hajaj, Barak, Fishilevich, Tali, Shagan, Marilou, Tal, Michael, Ellis, Ron, Morrison, Donald A., Mitchell, Andrea M., Mitchell, Timothy J., Dagan, Ron, Yesilkaya, Hasan, Nebenzahl, Yaffa Mizrachi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762878/
https://ncbi.nlm.nih.gov/pubmed/29321514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18645-8
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