Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function

Phosphorylation of the eukaryotic translation initiation factor, eIF2α, by stress-activated protein kinases and dephosphorylation by the growth arrest and DNA damage-inducible protein (GADD34)-containing phosphatase is a central node in the integrated stress response. Mass spectrometry demonstrated...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Lee, Irene Chengjie, Ho, Xue Yan, George, Simi Elizabeth, Goh, Catherine Wenhui, Sundaram, Jeyapriya Rajameenakshi, Pang, Karen Ka Lam, Luo, Weiwei, Yusoff, Permeen, Sze, Newman Siu Kwan, Shenolikar, Shirish
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2018
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762841/
https://ncbi.nlm.nih.gov/pubmed/28984870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.152
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