Genistein promotes ionizing radiation-induced cell death by reducing cytoplasmic Bcl-xL levels in non-small cell lung cancer

Genistein (GEN) has been previously reported to enhance the radiosensitivity of cancer cells; however, the detailed mechanisms remain unclear. Here, we report that GEN treatment inhibits the cytoplasmic distribution of Bcl-xL and increases nuclear Bcl-xL in non-small cell lung cancer (NSCLC). Intere...

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Опубликовано в: :Sci Rep
Главные авторы: Zhang, Zhimin, Jin, Feng, Lian, Xiaojuan, Li, Mengxia, Wang, Ge, Lan, Baohua, He, Hao, Liu, Guo-Dong, Wu, Yan, Sun, Guiyin, Xu, Cheng-Xiong, Yang, Zhen-Zhou
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762702/
https://ncbi.nlm.nih.gov/pubmed/29321496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18755-3
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