17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle

Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type-2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not...

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Pubblicato in:Cell Metab
Autori principali: Torres, Maria J., Kew, Kim A., Ryan, Terence E., Pennington, Edward Ross, Lin, Chien-Te, Buddo, Katherine A., Fix, Amy M., Smith, Cheryl A., Gilliam, Laura A., Karvinen, Sira, Lowe, Dawn A., Spangenburg, Espen E., Zeczycki, Tonya N., Shaikh, Saame Raza, Neufer, P. Darrell
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762397/
https://ncbi.nlm.nih.gov/pubmed/29103922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.10.003
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