Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis

Deoxypodophyllotoxin (DPT) is a naturally occurring flavolignan isolated from Anthriscus sylvestris. Recently, it has been reported that DPT inhibits tubulin polymerization and induces G2/M cell cycle arrest followed by apoptosis through multiple cellular processes. Despite these findings, details r...

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Vydáno v:Oncotarget
Hlavní autoři: Kim, Sang-Hun, Kim, Kwang-Youn, Park, Sul-Gi, Yu, Sun-Nyoung, Kim, Young-Wook, Nam, Hyo-Won, An, Hyun-Hee, Kim, Young-Woo, Ahn, Soon-Cheol
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762344/
https://ncbi.nlm.nih.gov/pubmed/29340076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22875
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