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Repeated-dose Oral N-acetylcysteine in Parkinson Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress
Parkinson disease (PD) is associated with oxidative stress and decreased nigral glutathione (GSH) suggesting that therapies that boost GSH may have a disease-modifying effect. Intravenous administration of a high dose of N-acetylcysteine (NAC), a well-known antioxidant and GSH precursor, increases b...
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| Publicado en: | J Clin Pharmacol |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5762253/ https://ncbi.nlm.nih.gov/pubmed/28940353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1008 |
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