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Elevated Pontine and Putamenal GABA Levels in Mild-Moderate Parkinson Disease Detected by 7 Tesla Proton MRS

BACKGROUND: Parkinson disease (PD) is characterized by the degeneration of nigrostriatal dopaminergic neurons. However, postmortem evidence indicates that the pathology of lower brainstem regions, such as the pons and medulla, precedes nigral involvement. Consistently, pontomedullary damage was impl...

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Détails bibliographiques
Auteurs principaux: Emir, Uzay E., Tuite, Paul J., Öz, Gülin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266292/
https://ncbi.nlm.nih.gov/pubmed/22295119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030918
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