Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells

Increased evidence suggests that somatic mutations in the ligand-binding domain of estrogen receptor [ER (ERα/ESR1)] are critical mediators of endocrine-resistant breast cancer progression. Insulinlike growth factor-1 (IGF1) is an essential regulator of breast development and tumorigenesis and also...

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Bibliografiske detaljer
Udgivet i:Endocrinology
Main Authors: Li, Zheqi, Levine, Kevin M., Bahreini, Amir, Wang, Peilu, Chu, David, Park, Ben Ho, Oesterreich, Steffi, Lee, Adrian V.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761602/
https://ncbi.nlm.nih.gov/pubmed/29029116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00693
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