Clinical Implications of the T790M Mutation in Disease Characteristics and Treatment Response in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (NSCLC)

BACKGROUND: The secondary T790M mutation accounts for more than 50% of acquired TKI resistance in EGFR-mutated NSCLC patients. Recent reports suggest this resistance mutation may be more common among patients with longer PFS on first-line TKI therapy, but much is still unknown. MATERIALS AND METHODS...

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Detalhes bibliográficos
Publicado no:Clin Lung Cancer
Main Authors: Gaut, Daria, Sim, Myung Shin, Yue, Yuguang, Wolf, Brian R., Abarca, Phillip A., Carroll, James M., Goldman, Jonathan W., Garon, Edward B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761337/
https://ncbi.nlm.nih.gov/pubmed/28712979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cllc.2017.06.004
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