EGFR mutation genotypes affect efficacy and resistance mechanisms of osimertinib in T790M-positive NSCLC patients

BACKGROUND: Osimertinib is a potent third-generation EGFR tyrosine kinase inhibitor (TKI) with robust activity in advanced EGFR-mutant non-small cell lung cancer (NSCLC), including those with T790M resistance mutation. However, a broad interpatient variability was observed. This study aimed to evalu...

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Detalhes bibliográficos
Publicado no:Transl Lung Cancer Res
Main Authors: Zheng, Qiufan, Huang, Yan, Zhao, Hongyun, Yang, Yunpeng, Hong, Shaodong, Hou, Xue, Zhao, Yuanyuan, Ma, Yuxiang, Zhou, Ting, Zhang, Yaxiong, Fang, Wenfeng, Zhang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354104/
https://ncbi.nlm.nih.gov/pubmed/32676311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr.2020.03.35
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