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Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain
The Pax gene family encodes DNA binding transcription factors that control critical steps in embryonic development and differentiation of specific cell lineages. Often, Pax proteins are re-expressed or ectopically expressed in cancer and other diseases of abnormal proliferation, making them attracti...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5761330/ https://ncbi.nlm.nih.gov/pubmed/28094913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00782 |
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