Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitochondria. Here, we report that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hu, Mengjie, Luo, Qiang, Alitongbieke, Gulimiran, Chong, Shuyi, Xu, Chenting, Xie, Lei, Chen, Xiaohui, Zhang, Duo, Zhou, Yuqi, Wang, Zhaokai, Ye, Xiaohong, Cai, Lijun, Zhang, Fang, Chen, Huibin, Jiang, Fuquan, Fang, Hui, Yang, Shanjun, Liu, Jie, Diaz-Meco, Maria T., Su, Ying, Zhou, Hu, Moscat, Jorge, Lin, Xiangzhi, Zhang, Xiao-kun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761061/
https://ncbi.nlm.nih.gov/pubmed/28388439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados