Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitochondria. Here, we report that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit...

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書誌詳細
出版年:Mol Cell
主要な著者: Hu, Mengjie, Luo, Qiang, Alitongbieke, Gulimiran, Chong, Shuyi, Xu, Chenting, Xie, Lei, Chen, Xiaohui, Zhang, Duo, Zhou, Yuqi, Wang, Zhaokai, Ye, Xiaohong, Cai, Lijun, Zhang, Fang, Chen, Huibin, Jiang, Fuquan, Fang, Hui, Yang, Shanjun, Liu, Jie, Diaz-Meco, Maria T., Su, Ying, Zhou, Hu, Moscat, Jorge, Lin, Xiangzhi, Zhang, Xiao-kun
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761061/
https://ncbi.nlm.nih.gov/pubmed/28388439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.008
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