Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitochondria. Here, we report that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Cell
मुख्य लेखकों: Hu, Mengjie, Luo, Qiang, Alitongbieke, Gulimiran, Chong, Shuyi, Xu, Chenting, Xie, Lei, Chen, Xiaohui, Zhang, Duo, Zhou, Yuqi, Wang, Zhaokai, Ye, Xiaohong, Cai, Lijun, Zhang, Fang, Chen, Huibin, Jiang, Fuquan, Fang, Hui, Yang, Shanjun, Liu, Jie, Diaz-Meco, Maria T., Su, Ying, Zhou, Hu, Moscat, Jorge, Lin, Xiangzhi, Zhang, Xiao-kun
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761061/
https://ncbi.nlm.nih.gov/pubmed/28388439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.008
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