Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Epigenomic abnormalities caused by genetic mutation in epigenetic regulators can result in neurodevelopmental disorders, deficiency in neural plasticity and mental retardation. As a histone demethylase, plant homeodomain finger protein 8 (Phf8) is a candidate gene for syndromal and non-specific form...

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I publikationen:Nat Commun
Huvudupphovsmän: Chen, Xuemei, Wang, Shuai, Zhou, Ying, Han, Yanfei, Li, Shengtian, Xu, Qing, Xu, Longyong, Zhu, Ziqi, Deng, Youming, Yu, Lu, Song, Lulu, Chen, Adele Pin, Song, Juan, Takahashi, Eiki, He, Guang, He, Lin, Li, Weidong, Chen, Charlie Degui
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760733/
https://ncbi.nlm.nih.gov/pubmed/29317619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02531-y
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