Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Epigenomic abnormalities caused by genetic mutation in epigenetic regulators can result in neurodevelopmental disorders, deficiency in neural plasticity and mental retardation. As a histone demethylase, plant homeodomain finger protein 8 (Phf8) is a candidate gene for syndromal and non-specific form...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Xuemei, Wang, Shuai, Zhou, Ying, Han, Yanfei, Li, Shengtian, Xu, Qing, Xu, Longyong, Zhu, Ziqi, Deng, Youming, Yu, Lu, Song, Lulu, Chen, Adele Pin, Song, Juan, Takahashi, Eiki, He, Guang, He, Lin, Li, Weidong, Chen, Charlie Degui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760733/
https://ncbi.nlm.nih.gov/pubmed/29317619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02531-y
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