GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar d-allulose (d-psicose), induces...

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Udgivet i:Nat Commun
Main Authors: Iwasaki, Yusaku, Sendo, Mio, Dezaki, Katsuya, Hira, Tohru, Sato, Takehiro, Nakata, Masanori, Goswami, Chayon, Aoki, Ryohei, Arai, Takeshi, Kumari, Parmila, Hayakawa, Masaki, Masuda, Chiaki, Okada, Takashi, Hara, Hiroshi, Drucker, Daniel J., Yamada, Yuichiro, Tokuda, Masaaki, Yada, Toshihiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760716/
https://ncbi.nlm.nih.gov/pubmed/29317623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02488-y
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