Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

The sensitivity of bioluminescence imaging in animals is primarily dependent on the amount of photons emitted by the luciferase enzyme at wavelengths greater than 620 nm where tissue penetration is high. This area of work has been dominated by firefly luciferase and its substrate, D-luciferin, due t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hall, Mary P., Woodroofe, Carolyn C., Wood, Monika G., Que, Ivo, van’t Root, Moniek, Ridwan, Yanto, Shi, Ce, Kirkland, Thomas A., Encell, Lance P., Wood, Keith V., Löwik, Clemens, Mezzanotte, Laura
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760652/
https://ncbi.nlm.nih.gov/pubmed/29317625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02542-9
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