Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at l...

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Udgivet i:Nat Commun
Main Authors: Fellows, Rachel, Denizot, Jérémy, Stellato, Claudia, Cuomo, Alessandro, Jain, Payal, Stoyanova, Elena, Balázsi, Szabina, Hajnády, Zoltán, Liebert, Anke, Kazakevych, Juri, Blackburn, Hector, Corrêa, Renan Oliveira, Fachi, José Luís, Sato, Fabio Takeo, Ribeiro, Willian R., Ferreira, Caroline Marcantonio, Perée, Hélène, Spagnuolo, Mariangela, Mattiuz, Raphaël, Matolcsi, Csaba, Guedes, Joana, Clark, Jonathan, Veldhoen, Marc, Bonaldi, Tiziana, Vinolo, Marco Aurélio Ramirez, Varga-Weisz, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760624/
https://ncbi.nlm.nih.gov/pubmed/29317660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02651-5
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