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Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T cells in Chronic Infection

Understanding the mechanisms of CD4 memory T cell (Tmem) differentiation in malaria is critical for vaccine development. However, the metabolic regulation of CD4 Tmem differentiation is not clear, particularly in persistent infections. In this study, we investigated the role of fatty acid synthesis...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Ibitokou, Samad A., Dillon, Brian E., Sinha, Mala, Szczesny, Bartosz, Delgadillo, Añahi, Abdelrahman, Doaa Reda, Szabo, Csaba, Abu-Elheiga, Lutfi, Porter, Craig, Tuvdendorj, Demidmaa, Stephens, Robin
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760294/
https://ncbi.nlm.nih.gov/pubmed/29237780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602110
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