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Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T cells in Chronic Infection

Understanding the mechanisms of CD4 memory T cell (Tmem) differentiation in malaria is critical for vaccine development. However, the metabolic regulation of CD4 Tmem differentiation is not clear, particularly in persistent infections. In this study, we investigated the role of fatty acid synthesis...

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發表在:J Immunol
Main Authors: Ibitokou, Samad A., Dillon, Brian E., Sinha, Mala, Szczesny, Bartosz, Delgadillo, Añahi, Abdelrahman, Doaa Reda, Szabo, Csaba, Abu-Elheiga, Lutfi, Porter, Craig, Tuvdendorj, Demidmaa, Stephens, Robin
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760294/
https://ncbi.nlm.nih.gov/pubmed/29237780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602110
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