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To what extent do structural changes in catalytic metal sites affect enzyme function?

About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold. The work presented here investigates how functional differentiation, within superfamilies that contain metalloenzymes, relat...

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Detalhes bibliográficos
Publicado no:J Inorg Biochem
Main Authors: Valasatava, Yana, Rosato, Antonio, Furnham, Nicholas, Thornton, Janet M., Andreini, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760197/
https://ncbi.nlm.nih.gov/pubmed/29161638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2017.11.002
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