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Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness

Papillomavirus E6 proteins bind to LXXLL peptide motifs displayed on targeted cellular proteins. Alpha genus HPV E6 proteins associate with the cellular ubiquitin ligase E6AP (UBE3A), by binding to an LXXLL peptide (ELTLQELLGEE) displayed by E6AP, thereby stimulating E6AP ubiquitin ligase activity....

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Brimer, Nicole, Drews, Camille M., Vande Pol, Scott B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760104/
https://ncbi.nlm.nih.gov/pubmed/29281732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006781
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