Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness

Papillomavirus E6 proteins bind to LXXLL peptide motifs displayed on targeted cellular proteins. Alpha genus HPV E6 proteins associate with the cellular ubiquitin ligase E6AP (UBE3A), by binding to an LXXLL peptide (ELTLQELLGEE) displayed by E6AP, thereby stimulating E6AP ubiquitin ligase activity....

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Publicat a:PLoS Pathog
Autors principals: Brimer, Nicole, Drews, Camille M., Vande Pol, Scott B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760104/
https://ncbi.nlm.nih.gov/pubmed/29281732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006781
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