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Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies
Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with gene network and phenotype information to identify...
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| Veröffentlicht in: | PLoS Genet |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760082/ https://ncbi.nlm.nih.gov/pubmed/29281626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007142 |
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