Progranulin plasma levels predict the presence of GRN mutations in asymptomatic subjects and do not correlate with brain atrophy: results from the GENFI study

We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers...

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I publikationen:Neurobiol Aging
Huvudupphovsmän: Galimberti, Daniela, Fumagalli, Giorgio G., Fenoglio, Chiara, Cioffi, Sara M.G., Arighi, Andrea, Serpente, Maria, Borroni, Barbara, Padovani, Alessandro, Tagliavini, Fabrizio, Masellis, Mario, Tartaglia, Maria Carmela, van Swieten, John, Meeter, Lieke, Graff, Caroline, de Mendonça, Alexandre, Bocchetta, Martina, Rohrer, Jonathan D., Scarpini, Elio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759894/
https://ncbi.nlm.nih.gov/pubmed/29146050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.10.016
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