Protease‐activated receptor 1 inhibition protects mice against thrombin‐dependent respiratory syncytial virus and human metapneumovirus infections

BACKGROUND AND PURPOSE: Protease‐activated receptor 1 (PAR1) has been demonstrated to be involved in the pathogenesis of viral diseases. However, its role remains controversial. The goal of our study was to investigate the contribution of PAR1 to respiratory syncytial virus (RSV) and human metapneum...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Lê, Vuong Ba, Riteau, Béatrice, Alessi, Marie‐Christine, Couture, Christian, Jandrot‐Perrus, Martine, Rhéaume, Chantal, Hamelin, Marie‐Ève, Boivin, Guy
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758388/
https://ncbi.nlm.nih.gov/pubmed/29105740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14084
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