Mutual influence of secondary and key drug‐resistance mutations on catalytic properties and thermal stability of TEM‐type β‐lactamases

Highly mutable β‐lactamases are responsible for the ability of Gram‐negative bacteria to resist β‐lactam antibiotics. Using site‐directed mutagenesis technique, we have produced in vitro a number of recombinant analogs of naturally occurring TEM‐type β‐lactamases, bearing the secondary substitution...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Grigorenko, Vitaly, Uporov, Igor, Rubtsova, Maya, Andreeva, Irina, Shcherbinin, Dmitrii, Veselovsky, Alexander, Serova, Oksana, Ulyashova, Maria, Ishtubaev, Igor, Egorov, Alexey
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757180/
https://ncbi.nlm.nih.gov/pubmed/29321962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12352
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