Mutual influence of secondary and key drug‐resistance mutations on catalytic properties and thermal stability of TEM‐type β‐lactamases

Highly mutable β‐lactamases are responsible for the ability of Gram‐negative bacteria to resist β‐lactam antibiotics. Using site‐directed mutagenesis technique, we have produced in vitro a number of recombinant analogs of naturally occurring TEM‐type β‐lactamases, bearing the secondary substitution...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Grigorenko, Vitaly, Uporov, Igor, Rubtsova, Maya, Andreeva, Irina, Shcherbinin, Dmitrii, Veselovsky, Alexander, Serova, Oksana, Ulyashova, Maria, Ishtubaev, Igor, Egorov, Alexey
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757180/
https://ncbi.nlm.nih.gov/pubmed/29321962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12352
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