The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural i...

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Vydáno v:Vaccine
Hlavní autoři: von Delft, Annette, Donnison, Timothy A., Lourenço, José, Hutchings, Claire, Mullarkey, Caitlin E., Brown, Anthony, Pybus, Oliver G., Klenerman, Paul, Chinnakannan, Senthil, Barnes, Eleanor
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756538/
https://ncbi.nlm.nih.gov/pubmed/29203182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.10.079
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