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Pooled screening for anti-proliferative inhibitors of protein-protein interactions
Protein-protein interactions (PPIs) are emerging as a promising new class of drug targets. Here, we present a novel high-throughput approach to screen inhibitors of PPIs in cells. We designed a library of 50,000 human peptide binding motifs and used a pooled lentiviral system to express them intrace...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5756068/ https://ncbi.nlm.nih.gov/pubmed/26900867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2026 |
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