Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and f...

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Publicat a:BMC Cancer
Autors principals: Gainetdinov, Ildar V., Skvortsova, Yulia V., Kondratieva, Sofia A., Klimov, Alexey, Tryakin, Alexey A., Azhikina, Tatyana L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755174/
https://ncbi.nlm.nih.gov/pubmed/29301509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3945-6
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