Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and f...

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Bibliografische gegevens
Gepubliceerd in:BMC Cancer
Hoofdauteurs: Gainetdinov, Ildar V., Skvortsova, Yulia V., Kondratieva, Sofia A., Klimov, Alexey, Tryakin, Alexey A., Azhikina, Tatyana L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755174/
https://ncbi.nlm.nih.gov/pubmed/29301509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3945-6
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