Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and f...

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Bibliografiska uppgifter
I publikationen:BMC Cancer
Huvudupphovsmän: Gainetdinov, Ildar V., Skvortsova, Yulia V., Kondratieva, Sofia A., Klimov, Alexey, Tryakin, Alexey A., Azhikina, Tatyana L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755174/
https://ncbi.nlm.nih.gov/pubmed/29301509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3945-6
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