Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BACKGROUND: Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenesis and f...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Gainetdinov, Ildar V., Skvortsova, Yulia V., Kondratieva, Sofia A., Klimov, Alexey, Tryakin, Alexey A., Azhikina, Tatyana L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755174/
https://ncbi.nlm.nih.gov/pubmed/29301509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3945-6
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