Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

BACKGROUND: Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, representing three distinct resistance pathways. The mechanisms...

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Publicat a:Retrovirology
Autors principals: Fun, Axel, Leitner, Thomas, Vandekerckhove, Linos, Däumer, Martin, Thielen, Alexander, Buchholz, Bernd, Hoepelman, Andy I. M., Gisolf, Elizabeth H., Schipper, Pauline J., Wensing, Annemarie M. J., Nijhuis, Monique
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755036/
https://ncbi.nlm.nih.gov/pubmed/29304821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-017-0384-z
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