Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a (14)C-microtracer and therapeutic dose in cancer patients

INTRODUCTION: Niraparib (Zejula™) is a poly(ADP-ribose) polymerase inhibitor recently approved by the US Food and Drug Administration for the maintenance treatment of patients with recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or...

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發表在:Cancer Chemother Pharmacol
Main Authors: van Andel, L., Rosing, H., Zhang, Z., Hughes, L., Kansra, V., Sanghvi, M., Tibben, M. M., Gebretensae, A., Schellens, J. H. M., Beijnen, J. H.
格式: Artigo
語言:Inglês
出版: Springer Berlin Heidelberg 2017
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754411/
https://ncbi.nlm.nih.gov/pubmed/29043410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3455-x
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