C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC)(n)-containing RNAs into poly-dipeptides can initiate in vivo witho...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Cheng, Weiwei, Wang, Shaopeng, Mestre, Alexander A., Fu, Chenglai, Makarem, Andres, Xian, Fengfan, Hayes, Lindsey R., Lopez-Gonzalez, Rodrigo, Drenner, Kevin, Jiang, Jie, Cleveland, Don W., Sun, Shuying
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754368/
https://ncbi.nlm.nih.gov/pubmed/29302060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02495-z
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