C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC)(n)-containing RNAs into poly-dipeptides can initiate in vivo witho...

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Vydáno v:Nat Commun
Hlavní autoři: Cheng, Weiwei, Wang, Shaopeng, Mestre, Alexander A., Fu, Chenglai, Makarem, Andres, Xian, Fengfan, Hayes, Lindsey R., Lopez-Gonzalez, Rodrigo, Drenner, Kevin, Jiang, Jie, Cleveland, Don W., Sun, Shuying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754368/
https://ncbi.nlm.nih.gov/pubmed/29302060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02495-z
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