MUC1-C INDUCES PD-L1 AND IMMUNE EVASION IN TRIPLE-NEGATIVE BREAST CANCER

The immune checkpoint ligand PD-L1 and the transmembrane mucin MUC1 are upregulated in triple-negative breast cancer (TNBC) where they contribute to its aggressive pathogenesis. Here we report that genetic or pharmacological targeting of the oncogenic MUC1 subunit MUC1-C is sufficient to suppress PD...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Maeda, Takahiro, Hiraki, Masayuki, Jin, Caining, Rajabi, Hasan, Tagde, Ashujit, Alam, Maroof, Bouillez, Audrey, Hu, Xiufeng, Suzuki, Yozo, Miyo, Masaaki, Hata, Tsuyoshi, Hinohara, Kunihiko, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754244/
https://ncbi.nlm.nih.gov/pubmed/29263152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1636
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