CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity

AIMS: PECAM-1 is an abundant endothelial cell surface receptor that becomes highly enriched at endothelial cell-cell junctions, where it functions to mediate leukocyte transendothelial migration, sense changes in shear and flow, and maintain the vascular permeability barrier. Homophilic interactions...

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Bibliografiska uppgifter
I publikationen:Life Sci
Huvudupphovsmän: Liao, Danying, Mei, Heng, Hu, Yu, Newman, Debra K., Newman, Peter J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754039/
https://ncbi.nlm.nih.gov/pubmed/29122551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2017.11.002
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