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Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells
A new bioorthogonal reactant pair, spiro[2.3]hex-1-ene (Sph) and 3,6-di-(2-pyridyl)-s-tetrazine (DpTz), for the strain-promoted inverse electron-demand Diels-Alder cycloaddition, i.e., tetrazine ligation, is reported. Compared with the previously reported strained alkenes such as trans-cyclooctene (...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5753752/ https://ncbi.nlm.nih.gov/pubmed/28876923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05674 |
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