Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis

AIM: We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics. METHODS: Genotypes for selected UGT1A and ABCB1 SNPs were determined using a TaqMan(®) Genotyping OpenArray(™) and high-resolution melt analysis for rs8175347. A nonlinear mixed-effects mode...

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Publicat a:Pharmacogenomics
Autors principals: Naidoo, Anushka, Ramsuran, Veron, Chirehwa, Maxwell, Denti, Paolo, McIlleron, Helen, Naidoo, Kogieleum, Yende-Zuma, Nonhlanhla, Singh, Ravesh, Ngcapu, Sinaye, Chaudhry, Mamoonah, Pepper, Michael S, Padayatchi, Nesri
Format: Artigo
Idioma:Inglês
Publicat: Future Medicine Ltd 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753622/
https://ncbi.nlm.nih.gov/pubmed/29210323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2017-0144
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