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A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the ‘rule-of-two’ model

Drug-induced liver injury (DILI) is a major cause of drug failures in both the preclinical and clinical phase. Consequently, improving prediction of DILI at an early stage of drug discovery will reduce the potential failures in the subsequent drug development program. In this regard, high-content sc...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Arch Toxicol
Main Authors: Chen, Minjun, Tung, Chun-Wei, Shi, Qiang, Guo, Lei, Shi, Leming, Fang, Hong, Borlak, Jürgen, Tong, Weida
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753582/
https://ncbi.nlm.nih.gov/pubmed/24958025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-014-1276-9
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